Job Description
Job DescriptionThe successful candidate will have outstanding expertise in mouse handling and mouse procedures. They will be responsible for managing mouse colonies, performing project-specific in vivo experiments, intravenous injections of hematopoietic stem cells in humanized murine models, retro-orbital and submandibular blood collection, and blood cell FACS analyses and in vivo imaging. This is a collaborative role that will be partnering with other team members to assist with project-specific- in vivo experiments as well as other needs across the process development function. Role and Responsibilities:
- Hands-on role with a commitment to designing, conducting and analyzing in vivo studies to assess engraftment of hematopoietic stem cells.
- Execute pluripotent stem cell culture and differentiation into hematopoietic stem cells to support process development, optimization, and characterization.
- Document experimental procedures and results according to established guidelines; Perform statistical analysis of experimental data.
- Collaborate effectively within departmental teams, engage in team discussions to resolve issues, and lead projects with a fully integrated team to facilitate successful outcomes.
- Prior experience in bioreactor-based process development for iPSC-derived cell therapies is highly desirable.
Qualifications:
- Advanced degree (M.S. or Ph.D.) in molecular biology or pharmacology, with at least 2 years of industry experience is required
- Experience working with human induced pluripotent stem cells (iPSC), hematopoietic stem cells (HSC), and/or immune cell biology; including scale-up processes utilizing bioreactors such as PBS vertical wheel, Rotea counterflow centrifuge is required
- Proficiency with in-vivo techniques including animal handling, intra-bone and intravenous transplants, blood collection and tissue dissection
- Experience in standard processing techniques including flow cytometry, molecular biology assays such as CFUs, immunological assays, and aseptic cell culture technique is required
- Experience with experiment design tools such as FlowJo and practical knowledge of statistical analysis is required
- Strong organizational, analytical, problem-solving, root-cause-analysis, and trouble-shooting skills are required
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